Table of Contents > Health Dictionary > Hyper-IgM syndrome

Hyper-IgM syndrome

An X-linked immunodeficiency disorder with very low serum concentrations of IgG and IgA with a normal or a markedly elevated concentration of polyclonal IgM; secondary to a mutation in the CD40 ligand gene, leading to defective T cell–dependent, B-cell isotope switching affected boys develop recurrent bacterial infections in the first or second years of life.
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