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H-Y antigen

An antigen factor, dependent on the Y chromosome, responsible for the differentiation of the human embryo into the male phenotype by inducing the initially bipotential embryonic gonad to develop into a testis; in the absence of this antigen, the indifferent gonad develops into an ovary. There are at least two loci involved, an autosomal gene that generates the antigen and one that makes the receptor.
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