Table of Contents > Health Dictionary > Hemoglobin S

Hemoglobin S

An abnormal Hb with substitution of a valyl residue for a glutamyl residue at the sixth position of the chain; the formula is a2A2S, or, more specifically, a2A26Glu?Val. Heterozygous state: sickle cell trait, no anemia, Hb S 2045% of total, the rest Hb A. Homozygous state: sickle cell anemia, Hb S 75100% of total, the rest Hb F or Hb A2.
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