1825
Table of Contents > Health Dictionary > Hemoglobin F (hereditary persistence of)

Hemoglobin F (hereditary persistence of)

A condition due to an allele that depresses synthesis of and chains (as in thalassemia), but this is fully compensated by increased ? chain synthesis and there is no anemia; there are 3 types: African type, no or chain synthesis by the chromosome with the abnormal gene, heterozygotes have 2030% Hb F and Hb A2 slightly decreased, homozygotes form no Hb A or Hb A2; Greek type, reduced and chain synthesis, heterozygotes have 1020% Hb F and normal Hb A2; Swiss type, heterozygotes have only 1 to 3% Hb F and normal Hb A2.
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